Why the study?
Does intracoronary norepinephrine infusion alter adenosine release and high energy phosphate concentrations in intact dog hearts?
Population
Anesthetized, open-chest dogs
Comparison
Intracoronary norepinephrine infusion for 16… vs Control period (baseline before infusion)
Design
Preclinical
Follow-up
16 minutes
Authors
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May explain coronary vasodilation during sympathetic stress without ischemia; hypothesis-generating in dogs and should not change practice.
Does intracoronary norepinephrine infusion alter adenosine release and high energy phosphate concentrations in intact dog hearts?
In intact dog hearts, norepinephrine-induced adenosine release can occur without significant sustained depletion of high energy phosphates or decreased oxygen supply/demand ratio.
Gorman et al. (1992) studied this question.
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