Supplementary Figure 2 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways

Key Points

• SIRT1 inhibition significantly reduces the growth of tumoral and metastatic granulosa cells.
• Key pathways affected include mTOR, Myc, and E2F, which are crucial for cell growth regulation.
• RNA-seq analysis revealed significant gene expression changes associated with SIRT1 inhibition.
• These findings suggest potential therapeutic targets for treating granulosa cell tumors.