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August 1, 2025

Supplementary Figure 2 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways

Victoria Cluzet Éloïse Airaud Arnaud Tête Marie M. Devillers Florence Petit Alexandra Léary Alice Pierre Haojian Li Chi‐Ping Day Urbain Weyemi Stéphanie Chauvin Céline J. Guigon

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Key Points

SIRT1 inhibition significantly reduces the growth of tumoral and metastatic granulosa cells.
Key pathways affected include mTOR, Myc, and E2F, which are crucial for cell growth regulation.
RNA-seq analysis revealed significant gene expression changes associated with SIRT1 inhibition.
These findings suggest potential therapeutic targets for treating granulosa cell tumors.

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Implication

Pharmacologic inhibition of SIRT1 limits tumoral growth in granulosa cells, indicating roles for mTOR and Myc pathways.

Abstract

PCA analyses of RNA-seq

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Cite This Study

Cluzet et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcb6 https://doi.org/10.1158/1535-7163.29761039

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Keep reading

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1Supplementary Figure 1 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways2025
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