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August 1, 2025

Supplementary Figure 1 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways

Victoria Cluzet Éloïse Airaud Arnaud Tête Marie M. Devillers Florence Petit Alexandra Léary Alice Pierre Haojian Li Chi‐Ping Day Urbain Weyemi Stéphanie Chauvin Céline J. Guigon

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Key Points

Inhibition of SIRT1 effectively limits the growth of tumoral and metastatic granulosa cells.
The study highlights the role of mTOR, Myc, and E2F pathways in tumor growth regulation.
Methods involved assessing SIRT1 expression and its effects on cellular growth mechanisms.
This research could lead to new targeted therapies for controlling tumor growth based on SIRT1 pathways.

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Implication

SIRT1 inhibition limits growth in tumoral and metastatic cells, suggesting mTOR and Myc may be involved.

Abstract

study of SIRT1 expression

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Cite This Study

Cluzet et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcbd https://doi.org/10.1158/1535-7163.29761042

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 2 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways2025
2Supplementary Figure 4 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways2025
3Data from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways2025 · 1 citations
4Preclinical evaluation of pharmacological inhibition of SIRT1 on the growth of tumoral and metastatic granulosa cells2024
5Supplementary Figure S10 from Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis2024