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August 1, 2025

Supplementary Figure 4 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways

Victoria Cluzet Éloïse Airaud Arnaud Tête Marie M. Devillers Florence Petit Alexandra Léary Alice Pierre Haojian Li Chi‐Ping Day Urbain Weyemi Stéphanie Chauvin Céline J. Guigon

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Key Points

MAIN FINDING: Inhibiting SIRT1 limits the growth of tumoral granulosa cells through mTOR and Myc pathways.
KEY EVIDENCE: RNA-seq analyses identified differentially expressed genes (DEGs) influenced by the inhibition treatment.
APPROACH: The study utilized RT-qPCR and RNA-seq for analyzing gene expressions in granulosa cells.
SIGNIFICANCE: This research highlights potential therapeutic strategies for targeting granulosa tumors by affecting key growth pathways.

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Implication

Pharmacologic inhibition of SIRT1 reduces granulosa cell growth, suggesting that targeting mTOR and Myc pathways may be effective in treatment.

Abstract

RT-qPCR analyses of selected DEGs identified by RNA-seq

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Cite This Study

Cluzet et al. (2025) studied this question.

synapsesocial.com/papers/689a0c6be6551bb0af8cfcc3 https://doi.org/10.1158/1535-7163.29761030

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 2 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways2025
2Supplementary Figure 1 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways2025
3Data from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways2025 · 1 citations
4Preclinical evaluation of pharmacological inhibition of SIRT1 on the growth of tumoral and metastatic granulosa cells2024
5Supplementary Figure S5 from Pharmacologic Inhibition of EIF4A Blocks NRF2 Synthesis to Prevent Osteosarcoma Metastasis2024