Supplementary Figure 4 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways
Key Points
MAIN FINDING: Inhibiting SIRT1 limits the growth of tumoral granulosa cells through mTOR and Myc pathways.
KEY EVIDENCE: RNA-seq analyses identified differentially expressed genes (DEGs) influenced by the inhibition treatment.
APPROACH: The study utilized RT-qPCR and RNA-seq for analyzing gene expressions in granulosa cells.
SIGNIFICANCE: This research highlights potential therapeutic strategies for targeting granulosa tumors by affecting key growth pathways.
Abstract
RT-qPCR analyses of selected DEGs identified by RNA-seq
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Supplementary Figure 4 from Pharmacologic Inhibition of SIRT1 Limits the Growth of Tumoral and Metastatic Granulosa Cells by Affecting mTOR, Myc, and E2F Pathways | Synapse