Table S4 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• MAIN FINDING: RGN6024 serves as a brain-penetrant small-molecule that destabilizes tubulin to target glioblastoma cells.
• KEY EVIDENCE: Experiments indicated effective βIII-tubulin overexpression response when treated with RGN6024.
• APPROACH: The study utilized βIII-tubulin overexpression experiments to evaluate the efficacy of RGN6024.
• SIGNIFICANCE: This finding highlights a novel therapeutic strategy for glioblastoma, a challenging brain tumor.