August 2, 2025

Table S4 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

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MAIN FINDING: RGN6024 serves as a brain-penetrant small-molecule that destabilizes tubulin to target glioblastoma cells.
KEY EVIDENCE: Experiments indicated effective βIII-tubulin overexpression response when treated with RGN6024.
APPROACH: The study utilized βIII-tubulin overexpression experiments to evaluate the efficacy of RGN6024.
SIGNIFICANCE: This finding highlights a novel therapeutic strategy for glioblastoma, a challenging brain tumor.

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Experimental data shows RGN6024 effectively targets tubulin in glioblastoma, indicating its potential as a therapeutic agent.

βIII-tubulin overexpression experiments with RGN6024

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Patrón et al. (2025) studied this question.

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Experimental data shows RGN6024 effectively targets tubulin in glioblastoma, indicating its potential as a therapeutic agent.

βIII-tubulin overexpression experiments with RGN6024