August 2, 2025

Table S9 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

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MAIN FINDING: RGN6024 demonstrates potential as a small-molecule tubulin destabilizer for glioblastoma treatment.
KEY EVIDENCE: Tests reveal enhanced cellular permeability of RGN6024 in brain tissues.
APPROACH: The study analyzes the effects of RGN6024 on tubulin dynamics in glioblastoma models.
SIGNIFICANCE: This research may open new pathways for therapeutic strategies against aggressive brain tumors.

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Pre-clinical findings show RGN6024 improves cellular permeability in glioblastoma cells, suggesting new therapeutic avenues.

Cellular permeability of RGN6024

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Patrón et al. (2025) studied this question.

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Pre-clinical findings show RGN6024 improves cellular permeability in glioblastoma cells, suggesting new therapeutic avenues.

Cellular permeability of RGN6024