August 2, 2025

Table S9 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

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RGN6024 is identified as a small-molecule tubulin destabilizer effective against glioblastoma.
The drug's cellular permeability allows it to penetrate the brain barrier, enhancing its effectiveness.
Research demonstrates that RGN6024 can disrupt microtubules, crucial for cancer cell structure and function.
The findings suggest RGN6024 may offer a new avenue for glioblastoma treatment, addressing a high-need area in oncology.

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The brain-penetrant drug RGN6024 improves cellular permeability in glioblastoma, indicating potential therapeutic benefits.

Cellular permeability of RGN6024

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Patrón et al. (2025) studied this question.

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The brain-penetrant drug RGN6024 improves cellular permeability in glioblastoma, indicating potential therapeutic benefits.

Cellular permeability of RGN6024