August 2, 2025

Table S8 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

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RGN6024 shows significant potential as a tubulin destabilizer for glioblastoma treatment.
In a xenograft model, RGN6024 effectively penetrates the brain, enabling therapeutic action.
Tumor and plasma levels of RGN6024 were measured to assess its pharmacokinetics and efficacy.
This research contributes to developing targeted therapies for glioblastoma, a challenging brain cancer.

Implication

Experimental findings reveal RGN6024's impact on brain and tumor levels in glioblastoma xenograft models, suggesting potential benefits in treatment.

Plasma, brain and tumor levels of RGN6024 in a subcutaneous LN-18 xenograft mouse model

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Patrón et al. (2025) studied this question.

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Experimental findings reveal RGN6024's impact on brain and tumor levels in glioblastoma xenograft models, suggesting potential benefits in treatment.

Plasma, brain and tumor levels of RGN6024 in a subcutaneous LN-18 xenograft mouse model