Table S10 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

Key Points

• MAIN FINDING: RGN6024 is identified as a brain-penetrant tubulin destabilizer for glioblastoma treatment.
• KEY EVIDENCE: Plasma and brain concentrations of RGN6024 were assessed after a 30 mg/kg oral dose in ICR mice.
• APPROACH: The study utilized ICR mice to analyze the drug's efficacy through oral administration.
• SIGNIFICANCE: This small-molecule agent may enhance treatment strategies for patients with glioblastoma by targeting brain tumors effectively.