August 2, 2025

Table S10 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

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MAIN FINDING: RGN6024 is identified as a brain-penetrant tubulin destabilizer for glioblastoma treatment.
KEY EVIDENCE: Plasma and brain concentrations of RGN6024 were assessed after a 30 mg/kg oral dose in ICR mice.
APPROACH: The study utilized ICR mice to analyze the drug's efficacy through oral administration.
SIGNIFICANCE: This small-molecule agent may enhance treatment strategies for patients with glioblastoma by targeting brain tumors effectively.

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Research shows RGN6024 increases brain levels in ICR mice after oral dosing, implying potential for glioblastoma therapy.

Plasma and brain levels of RGN6024 after a 30 mg/kg oral dose in ICR mice

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Patrón et al. (2025) studied this question.

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Research shows RGN6024 increases brain levels in ICR mice after oral dosing, implying potential for glioblastoma therapy.

Plasma and brain levels of RGN6024 after a 30 mg/kg oral dose in ICR mice