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Table S7 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma | Synapse
August 2, 2025
Table S7 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma
LP
Lilian A. Patrón
SilaGene (United States)
HY
Helen Yeoman
SilaGene (United States)
JR
Joseph Ramos
The University of Texas Health Science Center at San Antonio
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Key Points
MAIN FINDING: RGN6024 acts as a tubulin destabilizer, showing potential for treating glioblastoma effectively.
KEY EVIDENCE: Pharmacokinetic parameters in mice confirm robust brain penetration and favorable distribution.
APPROACH: The study involved administering RGN6024 to model mice and measuring its pharmacokinetic effects.
SIGNIFICANCE: RGN6024's brain-penetrant properties suggest enhanced therapeutic options for glioblastoma patients.
Abstract
Pharmacokinetic parameters for RGN6024 in mice
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Cite This Study
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Patrón et al. (Fri,) studied this question.
synapsesocial.com/papers/689a0c72e6551bb0af8d022f
https://doi.org/https://doi.org/10.1158/1535-7163.29760560