August 2, 2025

Table S7 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

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MAIN FINDING: RGN6024 acts as a tubulin destabilizer, showing potential for treating glioblastoma effectively.
KEY EVIDENCE: Pharmacokinetic parameters in mice confirm robust brain penetration and favorable distribution.
APPROACH: The study involved administering RGN6024 to model mice and measuring its pharmacokinetic effects.
SIGNIFICANCE: RGN6024's brain-penetrant properties suggest enhanced therapeutic options for glioblastoma patients.

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Pharmacokinetic analysis reveals RGN6024's effects on glioblastoma in mice, indicating strong brain penetration.

Pharmacokinetic parameters for RGN6024 in mice

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Patrón et al. (2025) studied this question.

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Pharmacokinetic analysis reveals RGN6024's effects on glioblastoma in mice, indicating strong brain penetration.

Pharmacokinetic parameters for RGN6024 in mice