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Synapse
August 2, 20250 citations

Table S11 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

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LPLilian A. PatrónHYHelen YeomanJRJoseph Ramos

Key Points

  • MAIN FINDING: RGN6024 effectively penetrates the brain, showing promise as a glioblastoma treatment.
  • KEY EVIDENCE: Pharmacokinetic studies reveal how RGN6024 behaves in plasma and brain tissues after administration.
  • APPROACH: The study involved pharmacokinetic analysis in rat models to assess RGN6024's brain penetration.
  • SIGNIFICANCE: Advancing glioblastoma therapies with RGN6024 could lead to improved patient outcomes due to its specific targeting mechanism.

Abstract

Plasma and brain pharmacokinetic parameters for RGN6024 in rats

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Cite This Study

Patrón et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0250https://doi.org/10.1158/1535-7163.29760587
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Table S11 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma2025
  2. 2Table S7 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma2025
  3. 3Table S7 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma2025
  4. 4Table S10 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma2025
  5. 5Table S10 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma2025