August 2, 2025

Table S8 from RGN6024 Is a Brain-Penetrant, Small-Molecule Tubulin Destabilizer for the Treatment of Glioblastoma

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MAIN FINDING: RGN6024 shows effective brain penetration as a tubulin destabilizer for glioblastoma treatment.
KEY EVIDENCE: It achieves substantial plasma and tumor levels in LN-18 xenograft mouse models, enhancing efficacy.
APPROACH: The research utilizes a subcutaneous LN-18 xenograft mouse model to assess RGN6024's pharmacokinetics.
SIGNIFICANCE: These findings indicate RGN6024 may provide a new therapeutic option for glioblastoma patients.

Implication

Preclinical findings demonstrate RGN6024's brain penetration and tumor targeting in xenograft mouse models, suggesting its potential as a therapy.

Plasma, brain and tumor levels of RGN6024 in a subcutaneous LN-18 xenograft mouse model

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Patrón et al. (2025) studied this question.

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Preclinical findings demonstrate RGN6024's brain penetration and tumor targeting in xenograft mouse models, suggesting its potential as a therapy.

Plasma, brain and tumor levels of RGN6024 in a subcutaneous LN-18 xenograft mouse model