Supplementary figure S5 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

• DECR2 regulates ferroptosis, influencing tumor growth and response to immunotherapy.
• Single-cell analysis showed differences in CD45+ immune cell profiles between control and decr2 KD tumors.
• B6 mice were used to model the effects of decr2 knockdown on immune cell populations.
• Findings highlight the importance of decr2 in modulating tumor immunity and treatment efficacy.