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August 1, 2025

Supplementary figure S5 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Shuyin Li Jason W. Shapiro Hardik Shah Emily F. Higgs Lishi Xie Yaopeng Li Yuanyuan Zha Jonathan Trujillo Alexandra Cabanov Tyler A. Jones Blake Flood Ken Hatogai Ruxandra Tonea Justin Kline Thomas F. Gajewski

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Key Points

DECR2 regulates ferroptosis, influencing tumor growth and response to immunotherapy.
Single-cell analysis showed differences in CD45+ immune cell profiles between control and decr2 KD tumors.
B6 mice were used to model the effects of decr2 knockdown on immune cell populations.
Findings highlight the importance of decr2 in modulating tumor immunity and treatment efficacy.

Implication

Single-cell transcriptomic profiling reveals changes in cd45+ cells in decr2 kd tumors of b6 mice, suggesting alterations in immune response.

Abstract

Supplementary Figure S5. Single-cell transcriptomic profiling of CD45+ cells isolated from control versus Decr2 KD tumors of B6 mice.

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d026c https://doi.org/10.1158/2326-6066.29760085

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary figure S1 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
2Supplementary figure S3 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
3Supplementary figure S11 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
4Supplementary figure S10 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
5Supplementary figure S2 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025

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Supplementary figure S13 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
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Supplementary figure S7 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025