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August 1, 2025

Supplementary figure S4 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Shuyin Li Jason W. Shapiro Hardik Shah Emily F. Higgs Lishi Xie Yaopeng Li Yuanyuan Zha Jonathan Trujillo Alexandra Cabanov Tyler A. Jones Blake Flood Ken Hatogai Ruxandra Tonea Justin Kline Thomas F. Gajewski

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Key Points

MAIN FINDING: Decr2 regulates ferroptosis, influencing tumor cell response to immunotherapy.
KEY EVIDENCE: CD8+ T cells show increased activation and cytokine secretion in the presence of Decr2.
APPROACH: The study analyzed immune responses in tumor-draining lymph nodes using mouse models.
SIGNIFICANCE: Understanding Decr2's role may improve immunotherapy strategies in cancer treatment.

Implication

Findings reveal CD8+ T cell activation and cytokine secretion in tumor-draining lymph nodes, suggesting impacts on immunotherapy efficacy.

Abstract

Supplementary Figure S4. CD8+ T cell activation and cytokine secretion in tumor-draining lymph nodes.

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d022c https://doi.org/10.1158/2326-6066.29760091

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary figure S7 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
2Supplementary figure S9 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
3Supplementary figure S16 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
4Supplementary figure S3 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
5Supplementary figure S1 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025

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