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August 1, 2025

Supplementary figure S9 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Shuyin Li Jason W. Shapiro Hardik Shah Emily F. Higgs Lishi Xie Yaopeng Li Yuanyuan Zha Jonathan Trujillo Alexandra Cabanov Tyler A. Jones Blake Flood Ken Hatogai Ruxandra Tonea Justin Kline Thomas F. Gajewski

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Key Points

MAIN FINDING: Decr2 regulates ferroptosis and influences immunotherapy efficacy in tumor cells.
KEY EVIDENCE: The study highlights expression levels of MHC class I and PD-L1 that affect tumor immune response.
APPROACH: Analyses were conducted on tumor cells to assess antigen presentation and immune markers.
SIGNIFICANCE: Understanding these mechanisms can improve the effectiveness of immunotherapy in treating tumors.

Implication

Data shows MHC class I and PD-L1 levels in tumor cells, indicating their role in immunotherapy response.

Abstract

Supplementary Figure S9. MHC class I H2Kb, PD-L1 expression, and antigen presentation by tumor cells.

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d027c https://doi.org/10.1158/2326-6066.29760070

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary figure S7 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
2Supplementary figure S4 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
3Supplementary figure S3 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
4Supplementary figure S16 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025
5Supplementary figure S1 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025

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Supplementary figure S5 from Tumor Cell–Intrinsic <i>Decr2</i> Regulates Ferroptosis and Immunotherapy Efficacy2025