Supplementary figure S16 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Shuyin Li; Jason W. Shapiro; Hardik Shah; Emily F. Higgs; Lishi Xie; Yaopeng Li; Yuanyuan Zha; Jonathan Trujillo; Alexandra Cabanov; Tyler A. Jones; Blake Flood; Ken Hatogai; Ruxandra Tonea; Justin Kline; Thomas F. Gajewski

doi:10.1158/2326-6066.29760106

August 1, 2025

Supplementary figure S16 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

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Key Points

MAIN FINDING: Decr2 is linked to ferroptosis and impacts the efficacy of immunotherapy.
KEY EVIDENCE: IFN-γ signaling plays a crucial role in T cell killing and lipid metabolism changes.
APPROACH: The findings stem from analyses involving immune responses and cellular lipid changes.
SIGNIFICANCE: Understanding these mechanisms could improve immunotherapy strategies against tumors.

Implication

Supplementary figure shows IFN-γ signaling enhances T cell killing through lipid reprogramming, highlighting potential implications for immunotherapy.

Abstract

Supplementary Figure S16. IFN-γ signaling is involved with T cell killing and reprogrammed lipids

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d023d https://doi.org/10.1158/2326-6066.29760106

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Supplementary figure S16 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary figure S16 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

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