Supplementary figure S2 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Shuyin Li; Jason W. Shapiro; Hardik Shah; Emily F. Higgs; Lishi Xie; Yaopeng Li; Yuanyuan Zha; Jonathan Trujillo; Alexandra Cabanov; Tyler A. Jones; Blake Flood; Ken Hatogai; Ruxandra Tonea; Justin Kline; Thomas F. Gajewski

doi:10.1158/2326-6066.29760097

August 1, 2025

Supplementary figure S2 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

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Key Points

Decr2 knockdown in OCI-Ly8 tumor cells led to resistance against CD19-CAR T cell killing in vitro.
B16.SIY tumors with Decr2 knockdown demonstrated resistance to anti-PD-L1 therapy in vivo.
The research highlights the importance of Decr2 in regulating ferroptosis related to tumor response.
Understanding the role of Decr2 may help improve immunotherapy strategies against cancers.

Implication

Decr2 knockdown shows resistance to CD19-CAR T cell killing in vitro and anti-PD-L1 therapy in vivo, suggesting a role in immunotherapy outcomes.

Abstract

Supplementary Figure S2. Decr2 knockdown OCI-Ly8 tumor cells were resistant to CD19-CAR T cell killing in vitro and Decr2 knockdown B16.SIY tumors exhibit resistance to anti-PD-L1 therapy in vivo.

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d02a8 https://doi.org/10.1158/2326-6066.29760097

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Supplementary figure S2 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary figure S2 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

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