Supplementary figure S17 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Shuyin Li; Jason W. Shapiro; Hardik Shah; Emily F. Higgs; Lishi Xie; Yaopeng Li; Yuanyuan Zha; Jonathan Trujillo; Alexandra Cabanov; Tyler A. Jones; Blake Flood; Ken Hatogai; Ruxandra Tonea; Justin Kline; Thomas F. Gajewski

doi:10.1158/2326-6066.29760103

August 1, 2025

Supplementary figure S17 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

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Key Points

Main finding indicates that slc7a11 gene depletion enhances immunotherapy response in tumor cells.
CRISPR screening revealed significant depletion of slc7a11 in B16.SIY cells with CD8+ T cells.
Research utilized double knockdown of Decr2 and slc7a11 to generate specific tumor cell models.
Understanding these mechanisms may improve ferroptosis and immunotherapy strategies in cancer treatment.

Implication

Genome-wide CRISPR identifies slc7a11 depletion in tumor cells, suggesting a link with immunotherapy effectiveness.

Abstract

Supplementary Figure S17. Genome-wide CRISPR reveals Slc7a11 gene was significantly depleted in B16.SIY cells co-cultured with 2C CD8+ T cells and Decr2 Slc7a11 double knockdown B16.SIY cells were generated.

Discussion

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/689a0c72e6551bb0af8d0226 https://doi.org/10.1158/2326-6066.29760103

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Supplementary figure S17 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

Supplementary figure S17 from Tumor Cell–Intrinsic Decr2 Regulates Ferroptosis and Immunotherapy Efficacy

Key Points

Implication

Abstract

Discussion

Cite This Study

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