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August 16, 2025Medicine and Pharmacy ReportsOpen Access

Pembrolizumab-induced fulminant triple M syndrome presenting with severe bradycardia

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Authors

MMMaia Ioana MihonCPCristina PamfilRBRuxandra Beyer

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Overview

Case report highlights the severe bradycardia and muscle weakness due to triple M syndrome, indicating heightened vigilance for immune-related adverse events.

Key Points

  • The patient developed severe bradycardia and muscle weakness after pembrolizumab therapy.
  • Despite echocardiography showing normal results, the patient faced worsening symptoms and respiratory failure.
  • A comprehensive diagnostic approach is essential as autoantibody markers may be absent in conditions like myocarditis.
  • Monitoring for immune-related adverse events is crucial for improving clinical outcomes in patients undergoing cancer treatment.

Cite This Study

Mihon et al. (2025) studied this question.

synapsesocial.com/papers/68a3688b0a429f797332de23https://doi.org/10.15386/mpr-2834
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