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August 16, 2025Medicine and Pharmacy ReportsOpen Access

Pembrolizumab-induced fulminant triple M syndrome presenting with severe bradycardia

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Authors

MMMaia Ioana MihonCPCristina PamfilRBRuxandra Beyer

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Overview

Case report highlights the severe bradycardia and muscle weakness due to triple M syndrome, indicating heightened vigilance for immune-related adverse events.

Key Points

  • The patient developed severe bradycardia and muscle weakness after pembrolizumab therapy.
  • Despite echocardiography showing normal results, the patient faced worsening symptoms and respiratory failure.
  • A comprehensive diagnostic approach is essential as autoantibody markers may be absent in conditions like myocarditis.
  • Monitoring for immune-related adverse events is crucial for improving clinical outcomes in patients undergoing cancer treatment.

Cite This Study

Mihon et al. (2025) studied this question.

synapsesocial.com/papers/68a3688b0a429f797332de23https://doi.org/10.15386/mpr-2834
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A41-21 An Uncommon Cause of Acute Respiratory Failure: Pembrolizumab-Induced Triple M Syndrome (Myocarditis, Myositis and Myasthenia Gravis)2026
  2. 2C49-21 Life-threatening Triple M Syndrome Induced By Pembrolizumab: A Rare Immune Checkpoint Inhibitor Complication2026
  3. 3Pembrolizumab-induced myocarditis with complete atrioventricular block and concomitant myositis in a metastatic bladder cancer patient: a case report and review of the literature2024 · 5 citations
  4. 4C49-22 When Three M's Collide: A Tale of Myasthenia Gravis, Myositis, and Myocarditis 2026
  5. 5Immune Checkpoint Inhibitor Overlap Syndrome: Myocarditis, Myositis, and Myasthenia Gravis in a Patient With Metastatic Melanoma2026 · 1 citations