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March 26, 2026CureusOpen Access

Immune Checkpoint Inhibitor Overlap Syndrome: Myocarditis, Myositis, and Myasthenia Gravis in a Patient With Metastatic Melanoma

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Authors

SBSamuel BennettAHAbhinav HarishHAHamad Althumairy

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Overview

Case illustrates severe myocarditis, myositis, and myasthenia gravis complications from immunotherapy, indicating urgency in diagnosis.

Key Points

  • To report a rare case of concurrent myocarditis, myositis, and myasthenia gravis induced by immune checkpoint inhibitors.
  • Detailed evaluation of clinical symptoms
  • Measurement of biomarkers such as troponin and creatine kinase
  • Use of echocardiography and electrocardiography
  • Endomyocardial biopsy for definitive diagnosis
  • Significant elevations in troponin and creatine kinase levels were observed
  • Patient developed rapid deterioration into cardiac and respiratory failure
  • Confirmed diagnosis of lymphocytic myocarditis with myocyte necrosis via biopsy
  • Patient's condition progressed despite treatment, leading to death

Cite This Study

Bennett et al. (2026) studied this question.

synapsesocial.com/papers/69c4cdb6fdc3bde44891a5b1https://doi.org/10.7759/cureus.105739
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