Figure S7 from B7-H3 CAR T Cells Are Effective against Ependymomas but Limited by Tumor Size and Immune Response

Key Points

• B7-H3 CAR T cells demonstrate effectiveness against ependymomas, but their efficacy is influenced by tumor size.
• Increased tumor size correlates with reduced B7-H3 CAR T cell expansion and treatment effectiveness in ependymomas.
• The inverse relationship between CAR T cell expansion and target antigen density suggests limitations in immune response.
• This understanding highlights the necessity to consider tumor characteristics in CAR T cell therapy for ependymomas.