Clostridium butyricum JJ100 and Lacticaseibacillus rhamnosus LR alleviate liver injury in mice caused by continuous high-dose-alcohol exposure by protecting the intestinal barrier, rebuilding the gut microbiota and regulating AMPK and TLR4/NF-κB signaling pathways

Key Points

• Probiotics significantly alleviate liver injury from alcohol exposure, restoring gut health and function.
• The treatment notably enhanced the intestinal barrier integrity, and regulated AMPK and TLR4/NF-κB pathways.
• Alcoholic liver disease (ALD) increases vulnerability to liver damage, impacting global public health challenges.
• This study highlights potential probiotic interventions for managing alcohol-induced liver complications.