Clostridium butyricum JJ100 and Lacticaseibacillus rhamnosus LR alleviate liver injury in mice caused by continuous high-dose-alcohol exposure by protecting the intestinal barrier, rebuilding the gut microbiota and regulating AMPK and TLR4/NF-κB signaling pathways

Yonghao Hu; Yujie Wang; Xudong Li; Qiong Xie; Zhitang Lyu

doi:10.1039/d5fo00915d

January 1, 2025Food & Function

Clostridium butyricum JJ100 and Lacticaseibacillus rhamnosus LR alleviate liver injury in mice caused by continuous high-dose-alcohol exposure by protecting the intestinal barrier, rebuilding the gut microbiota and regulating AMPK and TLR4/NF-κB signaling pathways

View Full Paper

Ask AI

Bookmark

Share

Key Points

Probiotics significantly alleviate liver injury from alcohol exposure, restoring gut health and function.
The treatment notably enhanced the intestinal barrier integrity, and regulated AMPK and TLR4/NF-κB pathways.
Alcoholic liver disease (ALD) increases vulnerability to liver damage, impacting global public health challenges.
This study highlights potential probiotic interventions for managing alcohol-induced liver complications.

Implication

Animal study shows reduced liver injury and improved gut microbiota in mice, suggesting benefits of probiotics on alcoholic liver disease.

Abstract

Alcohol consumption poses a major global public health challenge, with excessive drinkers showing heightened susceptibility to alcoholic liver disease (ALD) – a condition with complex pathogenesis.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Hu et al. (2025) studied this question.

synapsesocial.com/papers/68c19f9c54b1d3bfb60db515 https://doi.org/10.1039/d5fo00915d

View Full Paper

Ask AI

Bookmark

Share

Clostridium butyricum JJ100 and Lacticaseibacillus rhamnosus LR alleviate liver injury in mice caused by continuous high-dose-alcohol exposure by protecting the intestinal barrier, rebuilding the gut microbiota and regulating AMPK and TLR4/NF-κB signaling pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

Clostridium butyricum JJ100 and Lacticaseibacillus rhamnosus LR alleviate liver injury in mice caused by continuous high-dose-alcohol exposure by protecting the intestinal barrier, rebuilding the gut microbiota and regulating AMPK and TLR4/NF-κB signaling pathways

Key Points

Implication

Abstract

Discussion

Cite This Study

Keep reading

Keep reading