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September 10, 2025

Prevalence of Gram Negative Bacterial Isolates Causing Urinary Tract Infection With Their Antimicrobial Susceptibility Pattern at Tertiary Care Hospital, Rajkot.

Key Points

The study found that 18.5% of urine samples tested positive for UTI isolates.
E. coli was identified as the most common isolate, accounting for 64.86% of cases.
Carbapenems and aminoglycosides showed higher susceptibility compared to fluoroquinolones.
The data emphasizes the need for ongoing monitoring of antimicrobial susceptibility patterns.

Abstract

Introduction: Urinary tract infection is microbial invasion of urinary tract that extends from renal cortex to urethral meatus. Anatomically, upper UTI involves kidney and ureter and causes pyelonephritis and ureteritis while lower urethra involves urethra and bladder which causes cystitis, asymptomatic bacteriuria, urethritis and acute urethral syndrome. Based on source of infection,it can be catheter associated causing CAUTI or community acquired. UTI are the most common hospital acquired infection accounting for 35% of total HAIs in India.It involves all age groups and sexes but predominantly seen in females. Uropathogenic E.coli is the most common cause of all forms of UTI accounting for 70% of cases. In healthcare settings these agents are often multidrug resistant leading to increase in morbidity and healthcare expenditure. Aim- The objective of this study is to study the prevalence of Gram negative bacterial isolates causing urinary tract infection and their antimicrobial susceptibility pattern. Material And Methods- 200 urine samples were received at tertiary care hospital,Rajkot from December 2024 to May 2025 and were subjected to Gram stain, culture and biochemical reactions. Results- Out of 200 urine samples,37(18.5%) were positive for UTI isolates. UTI was more prevalent in females 22(59.45%) isolates compared to males 15(40.54%) isolates. Among females,21-40 year age group was more commonly affected(63.63%) while in males >60 year age group(60%) was more prone to UTI. E coli was the most common isolate(64.86%).Carbapenems and Aminoglycosides showed higher susceptibility compared to Fluoroquinolones and Cephalosporins. Conclusion- The present study reported E.coli as the most common pathogen causing UTI affecting mainly females. Aminoglycosides and Meropenem showed higher sensitivity.This study will help to improve treatment recommendations in a specific geographical region.It also allows the comparison of situation in Rajkot with other regions within and outside the state as well as country. Knowing the antimicrobial susceptibility pattern helps as an aid to treatment and judicious use of antibiotics.

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