Figure S13 from TGFβ Inhibition during Radiotherapy Enhances Immune Cell Infiltration and Decreases Metastases in Ewing Sarcoma

Key Points

• Inhibition of TGFβ enhances immune cell infiltration and reduces metastases in Ewing sarcoma tumors.
• Radiation therapy activates inflammatory pathways, significantly impacting tumor behavior in treated models.
• Using a hu-CD34+ mouse model, the findings illustrate a potential strategy to improve Ewing sarcoma treatment.
• The results highlight the need for further investigation into combining TGFβ inhibitors with radiotherapy.