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September 17, 2025

Whole-brain perfusion mapping in mice model for Alzheimer’s disease by dynamic BOLD MRI with transient hypoxia

Key Points

Dynamic BOLD MRI with transient hypoxia successfully indicated reductions in cerebral blood flow in Tg-SwDI mice without volume decrease.
Aged Tg-SwDI transgenic and wild-type mice underwent behavioral testing alongside imaging to assess cognitive changes.
The study used dynamic BOLD MRI as a noninvasive method to detect early biomarkers for dementia before physical volume changes were evident.
These findings highlight the possibility of utilizing this imaging technique for the early screening of dementia patients.

Abstract

Motivation: Drugs have been developed to slow the progression of cognitive decline. However, current biomarkers for early detection of dementia have limitations. Goal(s): To determine whether the newly developed dynamic blood oxygenation-level dependent (BOLD) MRI with transient hypoxia can help in early screening in a mouse model of Alzheimer's disease. Approach: 2, 4, and 6-month-old Tg-SwDI transgenic mice and wild-type mice underwent dynamic BOLD MRI with transient hypoxia, behavior test, and histopathology. Results: Dynamic BOLD MRI with transient hypoxia successfully showed cerebral blood flow and cerebral blood volume reduction in Tg-SwDI at age without cerebral volume reduction. Impact: Dynamic BOLD MRI with transient hypoxia can demonstrate cerebral perfusion changes before volume decline, suggesting the potential of this noninvasive technique as an early biomarker of dementia that may allow for screening of potential patients for dementia treatment.

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