November 30, 2025

High-grade 18F-PSMA-1007 Uptake of Benign Prostatic Hyperplasia With Chronic Inflammation

Key Points

High-grade PSMA uptake was identified in benign prostatic hyperplasia with chronic inflammation, indicating a possible diagnostic challenge.
PSMA uptake reached a maximum of 19 SUV in a case with a serum total prostate-specific antigen of 32.6 ng/mL.
Imaging with 18F-PSMA-1007 PET/CT and PET/MRI revealed heterogenous signals in the transition zone, complicating cancer detection.
May highlight the need for caution in interpreting PSMA imaging results, especially in patients with benign prostatic conditions.

Abstract

Benign prostatic hyperplasia can show low-grade PSMA uptake, but rarely shows high-grade PSMA uptake. We describe 18 F-PSMA-1007 PET/CT and PET/MRI findings in a case of large benign prostatic hyperplasia with chronic inflammatory infiltrates and a high level of serum total prostate-specific antigen (32.6 ng/mL). The large benign prostatic hyperplasia of the transition zone showed heterogeneous signal intensity on the T2-weighted image and heterogeneous intense PSMA uptake with SUV max of 19. This case indicates that benign prostatic hyperplasia with chronic inflammation can show high-grade PSMA uptake mimicking or masking prostate cancer of the central gland.

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Cite This Study

Man et al. (Wed,) studied this question.

synapsesocial.com/papers/692b9d8d1d383f2b2a379b7a https://doi.org/https://doi.org/10.1097/rlu.0000000000006153

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