High-grade 18F-PSMA-1007 Uptake of Benign Prostatic Hyperplasia With Chronic Inflammation

Benign prostatic hyperplasia can show low-grade PSMA uptake, but rarely shows high-grade PSMA uptake. We describe 18 F-PSMA-1007 PET/CT and PET/MRI findings in a case of large benign prostatic hyperplasia with chronic inflammatory infiltrates and a high level of serum total prostate-specific antigen (32.6 ng/mL). The large benign prostatic hyperplasia of the transition zone showed heterogeneous signal intensity on the T2-weighted image and heterogeneous intense PSMA uptake with SUV max of 19. This case indicates that benign prostatic hyperplasia with chronic inflammation can show high-grade PSMA uptake mimicking or masking prostate cancer of the central gland.