Weakly Coordinating Aldehyde as a Traceless Directing Group for Rhodium-Catalyzed Regioselective C-H Alkenylation of Benzaldehydes

Key Points

• This research aims to explore the use of weakly coordinating aldehydes as traceless directing groups in C-H alkenylation of benzaldehydes.
• Developed a rhodium-catalyzed reaction for C-H alkenylation.
• Utilized acrylates as alkenyl surrogates.
• Studied various benzaldehydes in the reaction.
• Demonstrated successful regioselective alkenylation of benzaldehydes.
• Showed that weakly coordinating aldehydes can effectively direct the reaction.
• Highlighted the efficiency and scope of this catalytic method.