Weakly Coordinating Aldehyde as a Traceless Directing Group for Rhodium-Catalyzed Regioselective C-H Alkenylation of Benzaldehydes

Jingwen Jia; Hong-Yu Ma; Juan Fan; Xiao-Zuan Chen; Zhong-Wen Liu; Xian-Ying Shi

doi:10.1039/d5qo01713k

January 1, 2026Organic Chemistry Frontiers

Weakly Coordinating Aldehyde as a Traceless Directing Group for Rhodium-Catalyzed Regioselective C-H Alkenylation of Benzaldehydes

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Key Points

This research aims to explore the use of weakly coordinating aldehydes as traceless directing groups in C-H alkenylation of benzaldehydes.
Developed a rhodium-catalyzed reaction for C-H alkenylation.
Utilized acrylates as alkenyl surrogates.
Studied various benzaldehydes in the reaction.
Demonstrated successful regioselective alkenylation of benzaldehydes.
Showed that weakly coordinating aldehydes can effectively direct the reaction.
Highlighted the efficiency and scope of this catalytic method.

Implication

Rhodium-catalyzed C-H alkenylation enhances regioselective reactions in benzaldehydes, suggesting new synthetic opportunities.

Abstract

A rhodium-catalyzed regioselective C-H alkenylation of benzaldehydes has been developed employing acrylates as alkenyl surrogates, in which weakly coordinating aldehyde is rarely utilized as a traceless-directing group. This approach offers...

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Cite This Study

Jia et al. (2026) studied this question.

synapsesocial.com/papers/6975b229feba4585c2d6da75 https://doi.org/10.1039/d5qo01713k

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Weakly Coordinating Aldehyde as a Traceless Directing Group for Rhodium-Catalyzed Regioselective C-H Alkenylation of Benzaldehydes

Key Points

Implication

Abstract

Discussion

Cite This Study

Weakly Coordinating Aldehyde as a Traceless Directing Group for Rhodium-Catalyzed Regioselective C-H Alkenylation of Benzaldehydes

Key Points

Implication

Abstract

Discussion

Cite This Study

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