This approach demonstrates site-specific C-H alkynylation in drug analogues, implying a novel method for chemical modification.
Herein, we report a weakly coordinating amide-directed regioselective C–H alkynylation, enabling late-stage, site-specific modification of intricate drug and material analogues containing multiple reactive C–H bonds. Notably, this approach achieves divergent...
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Liu et al. (2026) studied this question.
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