This procedure demonstrates C-H alkylation yielding up to 90% in benzaldehyde derivatives, suggesting broader applications.
A simple rhodium-catalyzed conjugate addition of C-H bonds to maleimides directed by a weakly coordinating aldehyde group was developed as a facile protocol to synthesize ortho-alkylated benzaldehydes in moderate to excellent yields (up to 90% yield). This protocol features operational simplicity and broad substrate scope, and requires no transient directing group.
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Jia et al. (2025) studied this question.
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