Crystal engineering of cystic fibrosis drug ivacaftor: Salts, solvates, and hydrate forms with solubility and stability studies

Key Points

• The central aim is to enhance the solubility and stability of ivacaftor through various crystal forms.
• Utilized crystal engineering techniques to create salts, solvates, and hydrates of ivacaftor.
• Conducted solubility and stability studies on different crystal forms.
• Analyzed the impact of various formulations on the drug's properties.
• Identified specific crystalline forms of ivacaftor with improved solubility characteristics.
• Demonstrated that certain hydrates enhance stability compared to the parent compound.
• Achieved a marked increase in the drug's performance as a cystic fibrosis treatment.