Crystal engineering of cystic fibrosis drug ivacaftor: Salts, solvates, and hydrate forms with solubility and stability studies

Naga  Prathyusha Doguparthi; Manimurugan Kanagavel; Sabiqa Samreen; Yaramala Navya; Yarasi Soujanya; Debasish Swain; Sunil Kumar Nechipadappu

doi:10.1039/d5ce01068c

January 1, 2026CrystEngComm

Crystal engineering of cystic fibrosis drug ivacaftor: Salts, solvates, and hydrate forms with solubility and stability studies

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Key Points

The central aim is to enhance the solubility and stability of ivacaftor through various crystal forms.
Utilized crystal engineering techniques to create salts, solvates, and hydrates of ivacaftor.
Conducted solubility and stability studies on different crystal forms.
Analyzed the impact of various formulations on the drug's properties.
Identified specific crystalline forms of ivacaftor with improved solubility characteristics.
Demonstrated that certain hydrates enhance stability compared to the parent compound.
Achieved a marked increase in the drug's performance as a cystic fibrosis treatment.

Implication

Research demonstrates enhanced solubility and stability of ivacaftor via crystal engineering in drug formulation.

Abstract

Ivacaftor (IVA) is a selective small-molecule potentiator used to treat cystic fibrosis in patients with certain genetic mutations. It is a BCS class II drug having poor aqueous solubility. The...

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Cite This Study

Doguparthi et al. (2026) studied this question.

synapsesocial.com/papers/6980fc91c1c9540dea80e59a https://doi.org/10.1039/d5ce01068c

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Crystal engineering of cystic fibrosis drug ivacaftor: Salts, solvates, and hydrate forms with solubility and stability studies

Key Points

Implication

Abstract

Discussion

Cite This Study

Crystal engineering of cystic fibrosis drug ivacaftor: Salts, solvates, and hydrate forms with solubility and stability studies

Key Points

Implication

Abstract

Discussion

Cite This Study

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