Overcoming stromal barriers in pancreatic cancer via size-engineered carrier-free nano-prodrugs

Key Points

• The research aims to explore how size-engineered carrier-free nano-prodrugs can overcome stromal barriers in pancreatic cancer.
• Fabrication of carrier-free SNC4DC nanoparticles using reprecipitation.
• Evaluation of particle sizes ranging from 30 to 400 nm.
• Assessment of SN-38 release rates and cellular uptake in pancreatic cancer models.
• Smaller nanoparticles (30 nm) demonstrated faster drug release compared to larger particles.
• 30-nm nanoparticles showed superior tumor inhibition effects in pancreatic cancer models.