Demonstrates enhanced tumor inhibition in pancreatic cancer using size-engineered nano-prodrugs, suggesting a novel therapeutic strategy.
Carrier-free SNC4DC nanoparticles (30–400 nm) were fabricated by reprecipitation. Smaller particles showed faster SN-38 release and cellular uptake, and 30-nm nanoparticles achieved superior tumor inhibition in pancreatic cancer models.
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Yang et al. (2026) studied this question.
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