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January 1, 2026RSC PharmaceuticsOpen Access

Development of betaine–aloe vera–gelatin hydrogel formulation for the treatment of burn wounds

Rohan Dattatray Londhe Shikha Tripathi Obulapathi Ummadisetty Anurag Kumar Singh Deepak Chouhan Avanish Singh Parmar Vinod Tiwari

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Key Points

The aim is to develop a hydrogel formulation utilizing betaine, aloe vera, and gelatin to improve burn wound healing.
Formulated a hydrogel combining betaine, aloe vera, and gelatin.
Evaluated the hydrogel's effectiveness in healing burn wounds through a randomized trial.
Assessed infection rates and scarring in treated wounds.
The hydrogel significantly reduced healing time compared to standard treatment.
Lower infection rates were observed in the hydrogel group (p<0.05).
Scarring was also minimized in patients using the hydrogel formulation.

Implication

Demonstrates improved healing in burn wounds, suggesting a novel treatment option.

Abstract

Burn wounds present a significant clinical challenge, often leading to prolonged healing, infection, and substantial scarring.

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Cite This Study

Londhe et al. (2026) studied this question.

synapsesocial.com/papers/6a323e9ed50b63ecad207cc3 https://doi.org/10.1039/d6pm00049e

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Design and Development of Advanced Biocompatible Hydrogels for Burn Wound Healing Applications2025
2The Potential of Functional Hydrogels in Burns Treatment2025 · 8 citations
3Effect of Spray-Type Alginate Hydrogel Dressing on Burn Wounds2024 · 12 citations
4Design And Characterization Of Regenerative Potential In Full Thickness Burn Wound Model2024
5Plant-Based Hydrogel Dressings in Burn Care: Biomolecular Mechanisms, Biofunctional Advantages, and Translational Challenges2025

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Aloe vera Gel-Loaded Alginate Hydrogel Beads for Controlled Wound Healing: A Comprehensive Review of Formulation, Ionic Gelation and In-Vitro Evaluation2026
Adhesive, Stretchable, and Photothermal Antibacterial Hydrogel Dressings for Wound Healing of Infected Skin Burn at Joints2024
Emulgel based on fish skin collagen‐microalgae‐silver increased neovascularization and re‐epithelialization of full thickness burn in rats2024

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