What question did this study set out to answer?

The aim is to assess the antioxidant efficacy of C. nummularius extract against phenylhydrazine-induced hyperbilirubinemia in a rat model.

February 8, 2026

Antioxidant efficacy of Cotoneaster nummularius in phenylhydrazine-induced hyperbilirubinemia: A rat model study.

FVFaezeh ValipourIslamic Azad University, Tehran AAAkbar Safipour AfsharIslamic Azad University, Tehran MAMohammad AzadbakhtMazandaran University of Medical Sciences

Key Points

The aim is to assess the antioxidant efficacy of C. nummularius extract against phenylhydrazine-induced hyperbilirubinemia in a rat model.
Administered C. nummularius extract at varying doses (5 mg/kg) to assess effects on liver function.
Induced hyperbilirubinemia using phenylhydrazine in rats to model oxidative damage.
Measured levels of bilirubin and oxidative stress markers in liver tissue.
C. nummularius extract significantly reduced bilirubin levels in a dose-dependent manner.
Antioxidant activity was notably highest at the 5 mg/kg dosage.
The extract demonstrated potential hepatoprotective effects against oxidative stress.

Abstract

These findings highlight the hepatoprotective potential of C. nummularius extract in reducing oxidative stress and hyperbilirubinemia. CNE dose-dependent effects, particularly at 5 mg/kg, suggest its promise as a therapeutic agent for neonatal liver dysfunction and oxidative damage. Further clinical studies are warranted to explore its potential applications in managing liver disorders.

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