What question did this study set out to answer?

This research investigates the antioxidant and hepatoprotective effects of naringin against oxidative liver injury.

July 9, 2026

Naringin from Citrus macroptera as a potential lead compound against oxidative liver injury

Key Points

This research investigates the antioxidant and hepatoprotective effects of naringin against oxidative liver injury.
In vivo experiments conducted on Swiss albino mice to assess the impact of naringin on liver enzymes and antioxidant levels.
Molecular docking and 200 ns molecular dynamics simulations were performed to evaluate the binding affinity of naringin against tyrosine kinase.
Characterization of naringin was done using NMR, FTIR, and mass spectrometry.
Naringin restored levels of antioxidant enzymes (SOD, CAT, GR) in mice liver tissues after oxidative stress exposure.
Liver injury markers (ALT and AST) significantly decreased with naringin treatment, indicating hepatoprotection.
ADMET analysis showed naringin has an acceptable pharmacokinetic and toxicity profile.

Abstract

Naringin, a bioactive flavonoid extracted from Citrus macroptera, was tested for its antioxidant and hepatoprotective effects against oxidative stress caused by carbon tetrachloride (CCl4) through its mechanisms. The structural characterisation was carried out with NMR, FTIR, and mass spectrometry. In vivo experiments in Swiss albino mice showed that naringin had a significant role in restoring antioxidant enzymes (SOD, CAT, and GR) and decreasing high levels of liver injury (ALT and AST), thus exhibiting hepatoprotection. Molecular docking of 2HCK against tyrosine kinase (PDB ID: 2HCK) showed high binding affinity which is further supported by a 200 ns molecular dynamics simulation. ADMET analysis indicated acceptable predicted pharmacokinetic and toxicity profile. In sum, naringin has potential antioxidant properties that can be used as a possible natural lead molecule in oxidative stress disorders.

KI fragen

Bookmark

View Full Paper