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February 12, 2026Food & Function5 citations

Genetic modulation of omega-3 and omega-6 polyunsaturated fatty acid metabolism and health outcomes: A systematic review

RPRodolfo PaolettiJMJ. Alfredo MartínezJTJoao Tomé-Carneiro

Key Points

  • This research aims to understand how genetic variations affect the metabolism of omega-3 and omega-6 fatty acids and their health impacts.
  • Conducted a systematic review of existing literature
  • Analyzed inter-individual responses to PUFA interventions
  • Assessed the role of genetic factors in fatty acid metabolism
  • Significant variability in responses to omega-3 and omega-6 interventions was observed
  • Genetic differences were identified as key contributors to metabolic variations
  • Standardized dietary recommendations may not be applicable for everyone

Abstract

Background: Inter-individual responses to omega-3 and omega-6 polyunsaturated fatty acid (PUFA) interventions differ substantially, challenging standardized dietary recommendations. This variability may be attributed to genetic differences influencing fatty acid biosynthesis,...

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Cite This Study

Paoletti et al. (2026) studied this question.

synapsesocial.com/papers/698d6e3c5be6419ac0d53bfchttps://doi.org/10.1039/d5fo04964d
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