Selective Fluorescent Detection of Hydrogen Sulfide in the Brain microdialysate Using an ESIPT-Activated Probe | Synapse
February 12, 2026
Selective Fluorescent Detection of Hydrogen Sulfide in the Brain microdialysate Using an ESIPT-Activated Probe
Key Points
This research aims to improve the detection of hydrogen sulfide in the brain to better understand its functions as a neuromodulator.
Developed an ESIPT-activated fluorescent probe for specific detection
Utilized microdialysis to sample brain tissue
Conducted quantitative analysis in complex brain environments
Successfully detected hydrogen sulfide in brain microdialysate
Demonstrated minimal interference from other substances
Confirmed the role of hydrogen sulfide as a neuromodulator
Abstract
Hydrogen sulfide (H2S) has emerged as a key neuromodulator in the central nervous system, yet its accurate quantification in the complex brain system remains challenging due to strong interference from...