Selective Fluorescent Detection of Hydrogen Sulfide in the Brain microdialysate Using an ESIPT-Activated Probe

Qian Wang; Cong Luo; Jingyi Tang; Zhaolun Duan; Hui Pan; Huihui Wang; Haoyue Xiang; Hui Gu

doi:10.1039/d5an01258a

January 1, 2026The Analyst

Selective Fluorescent Detection of Hydrogen Sulfide in the Brain microdialysate Using an ESIPT-Activated Probe

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Key Points

This research aims to improve the detection of hydrogen sulfide in the brain to better understand its functions as a neuromodulator.
Developed an ESIPT-activated fluorescent probe for specific detection
Utilized microdialysis to sample brain tissue
Conducted quantitative analysis in complex brain environments
Successfully detected hydrogen sulfide in brain microdialysate
Demonstrated minimal interference from other substances
Confirmed the role of hydrogen sulfide as a neuromodulator

Implication

Fluorescent detection method quantifies hydrogen sulfide in brain microdialysate, highlighting its role as a neuromodulator.

Abstract

Hydrogen sulfide (H2S) has emerged as a key neuromodulator in the central nervous system, yet its accurate quantification in the complex brain system remains challenging due to strong interference from...

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/698d6ebb5be6419ac0d547bf https://doi.org/10.1039/d5an01258a

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Selective Fluorescent Detection of Hydrogen Sulfide in the Brain microdialysate Using an ESIPT-Activated Probe

Key Points

Implication

Abstract

Discussion

Cite This Study

Selective Fluorescent Detection of Hydrogen Sulfide in the Brain microdialysate Using an ESIPT-Activated Probe

Key Points

Implication

Abstract

Discussion

Cite This Study

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