What question did this study set out to answer?

This study aims to differentiate the urinary microbiome and metabolome in overactive bladder compared to healthy states.

February 13, 2026

Urinary Microbiome and Metabolome Differentiate Overactive Bladder from the Physiological State, and Reflect Recent Antibiotic Use and Treatment Response

Key Points

This study aims to differentiate the urinary microbiome and metabolome in overactive bladder compared to healthy states.
Analyzed bacterial composition in urine samples
Categorized data by patient phenotype and comorbidities
Examined effects of recent antibiotic use on microbiome
Assessed therapeutic response based on microbiota composition
Marked differences in microbiome profiles between overactive bladder and physiological states
Recent antibiotic exposure was linked to significant microbiota changes
Patient phenotypes showed distinct microbiota characteristics influencing treatment outcomes

Abstract

The study provides new understanding regarding the physiological bacterial composition of urine, as well as that in the context of OAB. Further, microbiota differed by patient phenotype, comorbidities, recent antibiotic exposure, and therapeutic response. The results inform strategies of microbiological modulation to augment existing therapeutic strategies.

Urinary Microbiome and Metabolome Differentiate Overactive Bladder from the Physiological State, and Reflect Recent Antibiotic Use and Treatment Response

Key Points

Abstract

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