Urinary Microbiome and Metabolome Differentiate Overactive Bladder from the Physiological State, and Reflect Recent Antibiotic Use and Treatment Response

Key Points

• This study aims to differentiate the urinary microbiome and metabolome in overactive bladder compared to healthy states.
• Analyzed bacterial composition in urine samples
• Categorized data by patient phenotype and comorbidities
• Examined effects of recent antibiotic use on microbiome
• Assessed therapeutic response based on microbiota composition
• Marked differences in microbiome profiles between overactive bladder and physiological states
• Recent antibiotic exposure was linked to significant microbiota changes
• Patient phenotypes showed distinct microbiota characteristics influencing treatment outcomes