What question did this study set out to answer?

To examine the expression of prostate-specific membrane antigen (PSMA) in a chronic subdural hematoma (cSDH) post-embolization.

February 14, 2026

Persistent PSMA Expression at a Subdural Hematoma Following Middle Meningeal Artery Embolization

Key Points

To examine the expression of prostate-specific membrane antigen (PSMA) in a chronic subdural hematoma (cSDH) post-embolization.
Case report of an 82-year-old male with prostate cancer.
Conducted 18 F-DCFPyL PET/CT imaging for rising PSA levels.
Identified intracranial PSMA uptake linked to a known cSDH.
Detected PSMA expression in the right frontoparietal convexity corresponding to cSDH.
Findings suggest inflammation-driven neoangiogenesis in cSDH.
Emphasized the need to differentiate PSMA uptake from metastatic disease.

Abstract

An 82-year-old man on active surveillance for low-risk prostate cancer underwent 18 F-DCFPyL PET/CT PET/CT for rising PSA. Imaging revealed interval progression of known intraprostatic malignancy. Interestingly, intracranial uptake was seen along the right frontoparietal convexity, corresponding to a known chronic subdural hematoma (cSDH) in this patient who had previously undergone middle meningeal artery embolization. This case highlights prostate-specific membrane antigen (PSMA) expression associated with cSDH, likely reflecting inflammation-driven neoangiogenesis. Recognition of such uptake is essential to avoid misinterpretation as metastatic disease and may provide novel insights into cSDH pathophysiology and potential therapeutic targets.

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Persistent PSMA Expression at a Subdural Hematoma Following Middle Meningeal Artery Embolization

Key Points

Abstract

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